We're an actual play D&D group who almost exclusively uses homebrew setting expansions in our games. Our first season is set in a world based on Eiichiro Oda's One Piece, and our second one is set in the Star Wars universe.
No matter where we end up, we're just a pack of chaos goblins in pretty hats. I have no idea how the DMs stay sane.
Lio has been trying to keep a crew of chaos gremlins sailing safely across the four blues and the grand line for four years now (but trust me- it feels more like seven). He streams our games on his twitch channel and keeps the madness going.